Principal Scientist – Early Program Monitoring, Device Product Assessment and Innovation

Job Summary

Merck is seeking a Principal Scientist – Early Program Monitoring, Device Product Assessment and Innovation in Boston, Suffolk County, US. This senior R5 role leads early‑phase and preclinical drug‑device combination projects, shaping delivery strategies from concept to development.

Key Responsibilities

• Lead early‑program monitoring for drug and drug‑device combination candidates.
• Define and optimize formulation attributes (stability, viscosity, concentration, delivery volume, excipient compatibility) to match target delivery models.
• Collaborate with Discovery, Pharmaceutics, Engineering, and Clinical teams to align product design with regulatory and commercial expectations.
• Drive device product assessment, risk analysis, and innovation pipelines.
• Mentor junior scientists and foster cross‑functional knowledge sharing.
• Prepare technical reports, presentations, and regulatory documentation.

Qualifications

• Ph.D. in Pharmaceutical Sciences, Chemical Engineering, or related field.
• 10+ years of experience in drug delivery, formulation development, and device integration.
• Proven track record of advancing preclinical programs to IND or clinical stages.
• Strong analytical, project management, and communication skills.
• Experience with FDA/EMA regulatory pathways for combination products.

Compensation & Benefits

Base salary: $164,342.27 annually, plus Merck’s comprehensive benefits package.

Location

Boston, Suffolk County, United States.

Frequently Asked Questions

What does a Principal Scientist in early program monitoring do?

They lead preclinical drug‑device projects, define formulation strategies, coordinate cross‑functional teams, and guide candidates toward clinical development.

What qualifications are required for this Merck position?

A Ph.D. in a relevant science, 10+ years of drug delivery experience, and a proven record of advancing combination products through regulatory pathways.

Where is the job located and what is the salary?

The role is based in Boston, Suffolk County, US, with a base salary of $164,342.27 per year.